BD-PN1924

AP1G1 Rabbit Polyclonal Antibody

常规抗体

AP1G1 ADTG CLAPG1

AP-1 complex subunit gamma-1 (Adapter-related protein complex 1 subunit gamma-1) (Adaptor protein complex AP-1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

164

O43747

https://www.uniprot.org/uniprotkb/O43747/entry

P22892

http://www.uniprot.org/uniprot/P22892

Synthesized peptide derived from part region of human protein

AP1G1 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

90kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Widely expressed.

Golgi apparatus . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm . Cytoplasm, perinuclear region . Cytoplasmic vesicle, clathrin-coated vesicle . Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (PubMed:12773381). Co-localizes with AFTPH/aftiphilin in the cytoplasm (PubMed:15758025). .

Lysosome;

function:Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.,similarity:Belongs to the adaptor complexes large subunit family.,similarity:Contains 1 GAE domain.,subcellular location:Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.,subunit:Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds RABEP1 and AP1GBP1.,tissue specificity:Widely expressed.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.