产品名称
ATG9B Rabbit Polyclonal Antibody
蛋白名称
Autophagy-related protein 9B (APG9-like 2) (Nitric oxide synthase 3-overlapping antisense gene protein) (Protein sONE)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q674R7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q674R7/entry
Mouse Swissprot No.
Q6EBV9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6EBV9
免疫原
Synthesized peptide derived from part region of human protein
特异性
ATG9B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012],
组织表达
Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.
细胞定位
Preautophagosomal structure membrane ; Multi-pass membrane protein . Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool (PubMed:18936157). The starvation-induced redistribution depends on ULK1 and ATG13 (PubMed:18936157). .
功能
function:Plays a role in autophagy.,induction:By hypoxia, leading to inhibit NOS3 expression.,miscellaneous:ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662 nucleotides. ATG9B transcription may a role in NOS3 transcription regulation.,similarity:Belongs to the ATG9 family.,tissue specificity:Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
