产品名称
ADAM8 Rabbit Polyclonal Antibody
蛋白名称
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P78325
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P78325/entry
Mouse Swissprot No.
Q05910
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q05910
免疫原
Synthesized peptide derived from part region of human protein
特异性
ADAM8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009],
组织表达
Expressed on neutrophils and monocytes.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
cofactor:Binds 1 zinc ion per subunit.,function:Possible involvement in extravasation of leukocytes.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed on neutrophils and monocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
