产品名称
TNR8 Rabbit Polyclonal Antibody
基因名称
TNFRSF8 CD30 D1S166E
蛋白名称
Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P28908
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P28908/entry
Mouse Swissprot No.
Q60846
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60846
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97525
免疫原
Synthesized peptide derived from part region of human protein
特异性
TNR8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 IHC-p: 50-200 ELISA 1:5000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
组织表达
[Isoform 2]: Detected in alveolar macrophages (at protein level).
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Cytoplasm .
信号通路
Cytokine-cytokine receptor interaction;
功能
disease:Most specific Hodgkin disease associated antigen.,function:Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.,PTM:Phosphorylated on serine and tyrosine residues.,similarity:Contains 6 TNFR-Cys repeats.,subunit:Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
