产品名称
APOH Rabbit Polyclonal Antibody
蛋白名称
Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Anticardiolipin cofactor) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P02749
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P02749/entry
Mouse Swissprot No.
Q01339
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q01339
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P26644
免疫原
Synthesized peptide derived from part region of human protein
特异性
APOH Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008],
组织表达
Expressed by the liver and secreted in plasma.
功能
function:Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.,miscellaneous:In addition to the conflicts shown in the feature table, PubMed:6587378 reports an N-glycosylation site at Asn-188.,online information:The Singapore human mutation and polymorphism database,similarity:Contains 4 Sushi (CCP/SCR) domains.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
