BD-PE0983

CA9 (Carbonic Anhydrase IX) (18H11) Mouse Monoclonal antibody

常规抗体

CA9

WB

Human

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

Full-length protein expressed in 293T cell transfected with human CA9 expression vector

WB 1:2000, IHC 1:50, FCM 1:100

49.7kDa

-20°C/1 year

Mouse

IgG2b

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-basebalance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

现货

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)