产品名称
TAOK2 Rabbit Polyclonal Antibody
基因名称
TAOK2 KIAA0881 MAP3K17 PSK PSK1 UNQ2971/PRO7431
蛋白名称
Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UL54
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UL54/entry
Mouse Swissprot No.
Q6ZQ29
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6ZQ29
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JLS3
免疫原
Synthesized peptide derived from part region of human protein
特异性
TAOK2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
组织表达
Ubiquitously expressed, with a higher level of expression in testis and brain.
细胞定位
Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Cytoplasm, cytoskeleton. Nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.; [Isoform 2]: Cell projection, dendrite. In dendrites, colocalizes with PCDH8. .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Found to be perinuclear and localized to vesicular compartment.,subunit:Interacts with MKK3 and MKK6 (By similarity). Self-associates.,tissue specificity:Ubiquitously expressed, with a higher level of expression in testis and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
