产品名称
RIPK3 Rabbit Polyclonal Antibody
蛋白名称
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y572
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y572/entry
Mouse Swissprot No.
Q9QZL0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QZL0
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9Z2P5
免疫原
Synthesized peptide derived from part region of human protein
特异性
RIPK3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. ; [Isoform 3]: Expression is significantly increased in colon and lung cancers.
细胞定位
Cytoplasm, cytosol . Nucleus . Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection. .
信号通路
Cytosolic DNA-sensing pathway;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Promotes apoptosis.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex.,tissue specificity:Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
