产品名称
TRIB2 Rabbit Polyclonal Antibody
蛋白名称
Tribbles homolog 2 (TRB-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92519
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92519/entry
Mouse Swissprot No.
Q8K4K3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K4K3
免疫原
Synthesized peptide derived from part region of human protein
特异性
TRIB2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009],
组织表达
Highly expressed in peripheral blood leukocytes.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . May associate with the cytoskeleton. .
功能
function:Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity.,miscellaneous:Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:May associate with the cytoskeleton.,tissue specificity:Highly expressed in peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
