产品名称
KGP1 Rabbit Polyclonal Antibody
基因名称
PRKG1 PRKG1B PRKGR1A PRKGR1B
蛋白名称
cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13976
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13976/entry
Mouse Swissprot No.
P0C605
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P0C605
免疫原
Synthesized peptide derived from part region of human protein
特异性
KGP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-bindin
组织表达
Primarily expressed in lung and placenta.
细胞定位
Cytoplasm . Colocalized with TRPC7 in the plasma membrane. .
信号通路
Vascular smooth muscle contraction;Gap junction;Long-term depression;Olfactory transduction;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,similarity:Belongs to the protein kinase superfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
