产品名称
CLK3 Rabbit Polyclonal Antibody
蛋白名称
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49761
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49761/entry
Mouse Swissprot No.
O35492
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35492
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63117
免疫原
Synthesized peptide derived from part region of human protein
特异性
CLK3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
CDC like kinase 3(CLK3) Homo sapiens This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008],
细胞定位
[Isoform 1]: Nucleus. Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome .; [Isoform 2]: Nucleus speckle. Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.,PTM:Autophosphorylates on all three types of residues.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
