产品名称
CSK22 Rabbit Polyclonal Antibody
蛋白名称
Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P19784
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P19784/entry
Mouse Swissprot No.
O54833
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54833
免疫原
Synthesized peptide derived from part region of human protein
特异性
CSK22 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,
细胞定位
Nucleus . Cytoplasm . Interaction with SIRT6 prevents translocation into the nucleus. .
信号通路
WNT;WNT-T CELLAdherens_Junction;Adherens_Junction;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
