产品名称
BAG2 Rabbit Polyclonal Antibody
蛋白名称
BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95816
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95816/entry
Mouse Swissprot No.
Q91YN9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91YN9
免疫原
Synthesized peptide derived from part region of human protein
特异性
BAG2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
功能
function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.,similarity:Contains 1 BAG domain.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
