产品名称
RASA2 Rabbit Polyclonal Antibody
蛋白名称
Ras GTPase-activating protein 2 (GAP1m)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15283
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15283/entry
Mouse Swissprot No.
P58069
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P58069
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63713
免疫原
Synthesized peptide derived from part region of human protein
特异性
RASA2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
细胞定位
Cytoplasm. Cytoplasm, perinuclear region.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;
功能
function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
