产品名称
CLK3 Rabbit Polyclonal Antibody
蛋白名称
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49761
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49761/entry
Mouse Swissprot No.
O35492
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35492
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63117
免疫原
Synthesized peptide derived from part region of human protein
特异性
CLK3 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
CDC like kinase 3(CLK3) Homo sapiens This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008],
细胞定位
[Isoform 1]: Nucleus. Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome .; [Isoform 2]: Nucleus speckle. Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.,PTM:Autophosphorylates on all three types of residues.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
