产品名称
AGFG1 Rabbit Polyclonal Antibody
蛋白名称
Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P52594
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P52594/entry
Mouse Swissprot No.
Q8K2K6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K2K6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q4KLH5
免疫原
Synthesized peptide derived from part region of human protein
特异性
AGFG1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
ArfGAP with FG repeats 1(AGFG1) Homo sapiens The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus . Cytoplasmic vesicle .
功能
domain:Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev.,function:Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.,PTM:O-glycosylated.,similarity:Contains 1 Arf-GAP domain.,subunit:Interacts with EPS15R and EPS15.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
