产品名称
PXK Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54899
Human Swissprot No.
Q7Z7A4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z7A4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/218699
Mouse Swissprot No.
Q8BX57
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BX57
Rat Gene Link
https://www.uniprot.org/uniprot/306203
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4FZZ1
免疫原
Synthesized peptide derived from human PXK AA range: 238-288
特异性
This antibody detects endogenous levels of PXK at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
组织表达
Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Also associates with the plasma membrane. Isoform 3 is present throughout the cell.
功能
domain:The protein kinase domain is predicted to be catalytically inactive.,function:Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.,sequence caution:Translated as Gly.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 1 WH2 domain.,subcellular location:Also associates with the plasma membrane. Isoform 3 is present throughout the cell.,tissue specificity:Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis, expression of isoform 7 has yet to be demonstrated.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
