产品名称
PK3CB Rabbit Polyclonal Antibody
蛋白名称
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P42338
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P42338/entry
Mouse Swissprot No.
Q8BTI9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BTI9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9Z1L0
免疫原
Synthesized peptide derived from part region of human protein
特异性
PK3CB Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],
组织表达
Expressed ubiquitously.
细胞定位
Cytoplasm . Nucleus . Interaction with PIK3R2 is required for nuclear localization and export.
信号通路
Inositol phosphate metabolism;ErbB_HER;Chemokine;Phosphatidylinositol signaling system;mTOR;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;VEGF;Focal adhesion;Toll_Like;Jak_STAT;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;B_
功能
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,function:Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.,tissue specificity:Expressed ubiquitously.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
