产品名称
CP4AM Rabbit Polyclonal Antibody
蛋白名称
Cytochrome P450 4A22 (CYPIVA22) (Fatty acid omega-hydroxylase) (Lauric acid omega-hydroxylase) (EC 1.14.15.3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q5TCH4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5TCH4/entry
免疫原
Synthesized peptide derived from part region of human protein AA range: 403-453
特异性
CP4AM Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
cytochrome P450 family 4 subfamily A member 22(CYP4A22) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .
信号通路
Fatty acid metabolism;Arachidonic acid metabolism;Retinol metabolism;PPAR;Vascular smooth muscle contraction;
功能
catalytic activity:Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O.,caution:Was originally (PubMed:10860550) termed CYP4A11.,function:Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.,online information:CYP4A22 alleles,similarity:Belongs to the cytochrome P450 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
