产品名称
PROP1 Rabbit Polyclonal Antibody
蛋白名称
Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75360
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75360/entry
Mouse Swissprot No.
P97458
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97458
免疫原
Synthesized peptide derived from part region of human protein
特异性
PROP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011],
组织表达
Expressed specifically in embryonic pituitary.
功能
disease:Defects in PROP1 are a cause of combined pituitary hormone deficiency (CPHD) [MIM:601538, 262600]. It is characterized by impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones.,function:Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.,similarity:Belongs to the paired homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed specifically in embryonic pituitary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
