产品名称
ATRN Rabbit Polyclonal Antibody
蛋白名称
Attractin (DPPT-L) (Mahogany homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75882
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75882/entry
Mouse Swissprot No.
Q9WU60
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WU60
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q99J86
免疫原
Synthesized peptide derived from part region of human protein
特异性
ATRN Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
attractin(ATRN) Homo sapiens This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016],
组织表达
Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .
功能
function:Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system.,induction:Activation of peripheral blood leukocytes with phytohemagglutinin induces strong expression of the membrane isoform followed by the release of the secreted isoform.,online information:Attractin-2,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 CUB domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 6 Kelch repeats.,tissue specificity:Expressed and secreted by activated T lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2/secreted is the major isoform in peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
