产品名称
ORC3 Rabbit Polyclonal Antibody
蛋白名称
Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBD5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBD5/entry
Mouse Swissprot No.
Q9JK30
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JK30
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q4R180
免疫原
Synthesized peptide derived from part region of human protein
特异性
ORC3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008],
组织表达
Brain,Liver,Testis,Uterus,
细胞定位
Nucleus . Chromosome .
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ORC3 family.,subunit:ORC is composed of six subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
