BD-PE0308-APP (Amyloid beta precursor protein) (16K7) Mouse Monoclonal antibody-现货抗体产品库武汉枢密脑科学技术有限公司

APP (Amyloid beta precursor protein) (16K7) Mouse Monoclonal antibody

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产品基本信息

产品货号

BD-PE0308

产品名称

APP (Amyloid beta precursor protein) (16K7) Mouse Monoclonal antibody

类别

常规抗体

基因名称

Amyloid Precursor Protein

推荐应用

反应种属

Human,Mouse,Rat

存储缓冲液

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

免疫原

Full length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.

稀释度

WB 1:2000, IHC 1:50, IF 1:100

预测分子量

87.0kDa

运输及保存条件

-20°C/1 year

宿主

Mouse

同种型

IgG2a

背景介绍

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

期货

现货

纯化

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0308)

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0308)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0308)

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0308)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0308)

Immunofluorescent staining of HT29 cells using anti-APP mouse monoclonal antibody (BD-PE0308).

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0308)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0308)

Anti-APP mouse monoclonal antibody (BD-PE0308) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY APP .

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP. Positive lysates (100ug) and (20ug) can be purchased separately from OriGene.