产品名称
E2F8 Rabbit Polyclonal Antibody
蛋白名称
Transcription factor E2F8 (E2F-8)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
A0AVK6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/A0AVK6/entry
Mouse Swissprot No.
Q58FA4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q58FA4
免疫原
Synthesized peptide derived from part region of human protein
特异性
E2F8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012],
组织表达
Lung,Mammary gland,Skin,Testis,
功能
domain:Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.,function:Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the E2F/DP family.,subunit:Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
