产品名称
CR3L3 Rabbit Polyclonal Antibody
基因名称
CREB3L3 CREBH HYST1481
蛋白名称
Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q68CJ9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q68CJ9/entry
Mouse Swissprot No.
Q91XE9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91XE9
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5FVM5
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-100
特异性
CR3L3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
组织表达
Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
信号通路
Melanogenesis;Huntington's disease;Prostate cancer;
功能
function:Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.,PTM:Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Binds DNA as a dimer (By similarity). Probably homodimerizes. Probably forms a heterodimer with atf6. Interacts with atf6.,tissue specificity:Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
