产品名称
MARE2 Rabbit Polyclonal Antibody
蛋白名称
Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15555
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15555/entry
Mouse Swissprot No.
Q8R001
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R001
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q3B8Q0
免疫原
Synthesized peptide derived from part region of human protein
特异性
MARE2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012],
组织表达
Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
细胞定位
Cytoplasm, cytoskeleton . Associated with the microtubule network. Accumulates at the plus end of microtubules.
功能
domain:Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.,function:May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.,similarity:Belongs to the MAPRE family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 EB1 C-terminal domain.,subcellular location:Associated with the microtubule network. Accumulates at the plus end of microtubules.,subunit:Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.,tissue specificity:Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
