BD-PE0113

MSH6 (11D15) Mouse Monoclonal antibody

常规抗体

MSH6

WB

Human,Mouse,Rat

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

Human recombinant protein fragment corresponding to amino acids 1-280 of human MSH6(NP_000170) produced in E.coli.

WB 1:2000, IHC 1:150

-20°C/1 year

Mouse

IgG1

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

现货

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)