产品名称
MCM8 Rabbit Polyclonal Antibody
蛋白名称
DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UJA3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UJA3/entry
Mouse Swissprot No.
Q9CWV1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CWV1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D3ZVK1
免疫原
Synthesized peptide derived from part region of human protein
特异性
MCM8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013],
组织表达
Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
细胞定位
Nucleus . Chromosome . Localizes to nuclear foci (PubMed:26215093). Localizes to double-stranded DNA breaks (PubMed:23401855). Binds chromatin throughout the cell cycle (PubMed:15684404). .
功能
function:May have a role in the control of cell proliferation. Appears to be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,subunit:Interacts with CDC6 and ORC2L.,tissue specificity:Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
