BD-PE0078-F13A1 (Factor XIIIa) (9G17) Mouse Monoclonal antibody-现货抗体产品库武汉枢密脑科学技术有限公司

F13A1 (Factor XIIIa) (9G17) Mouse Monoclonal antibody

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产品基本信息

产品货号

BD-PE0078

产品名称

F13A1 (Factor XIIIa) (9G17) Mouse Monoclonal antibody

类别

常规抗体

基因名称

F13A1

推荐应用

反应种属

Human,Mouse,Rat

存储缓冲液

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% New type preservative N.

免疫原

Full length human recombinant protein of human F13A1 (NP_000120) produced in HEK293T cell.

稀释度

WB 1:2000, IHC 1:150, FCM 1:100

预测分子量

79.2kDa

运输及保存条件

-20°C/1 year

宿主

Mouse

同种型

IgG1

背景介绍

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq]

期货

现货

纯化

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

HEK293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-F13A1 antibody (BD-PE0078), and then analyzed by flow cytometry.

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min, BD-PE0078)

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY F13A1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-F13A1(Cat# BD-PE0078). Positive lysates (100ug) and (20ug) can be purchased separately from OriGene.