产品名称
CC14B Rabbit Polyclonal Antibody
蛋白名称
Dual specificity protein phosphatase CDC14B (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O60729
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60729/entry
Mouse Swissprot No.
Q6PFY9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6PFY9
免疫原
Synthesized peptide derived from part region of human protein AA range: 407-457
特异性
CC14B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
cell division cycle 14B(CDC14B) Homo sapiens The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus, nucleolus. Nucleus, nucleoplasm. Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,domain:Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.,function:Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.,subcellular location:Nucleolar during interphase.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
