产品名称
MARE2 Rabbit Polyclonal Antibody
蛋白名称
Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15555
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15555/entry
Mouse Swissprot No.
Q8R001
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R001
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q3B8Q0
免疫原
Synthesized peptide derived from part region of human protein
特异性
MARE2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012],
组织表达
Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
细胞定位
Cytoplasm, cytoskeleton . Associated with the microtubule network. Accumulates at the plus end of microtubules.
功能
domain:Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.,function:May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.,similarity:Belongs to the MAPRE family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 EB1 C-terminal domain.,subcellular location:Associated with the microtubule network. Accumulates at the plus end of microtubules.,subunit:Interacts with DCTN1. Binds to the C-terminal domain of APC. Binds monomeric and polymerized tubulin.,tissue specificity:Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
