产品名称
DUS15 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/128853
Human Swissprot No.
Q9H1R2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H1R2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/252864
Mouse Swissprot No.
Q8R4V2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R4V2
免疫原
Synthesized peptide derived from human DUS15 AA range: 15-65
特异性
This antibody detects endogenous levels of DUS15 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
组织表达
Highly expressed in testis (PubMed:15138252). Expressed in brain; up-regulated in patients with multiple sclerosis gray matter lesions (PubMed:22792334).
细胞定位
Cytoplasm .; [Isoform 3]: Cell membrane; Lipid-anchor; Cytoplasmic side.
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,caution:Although assigned as two separate genes (c20orf57 and DUSP15), it is probable that C20orf57 does not exist by itself and is a part of the DUSP15 gene.,PTM:Isoform 3 is N-myristoylated.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Highly expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
