产品名称
SP130 Rabbit Polyclonal Antibody
蛋白名称
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H0E3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H0E3/entry
Mouse Swissprot No.
Q8BIH0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BIH0
免疫原
Synthesized peptide derived from part region of human protein
特异性
SP130 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008],
组织表达
Expressed in various cancer cell ines.
功能
domain:The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.,domain:The N-terminus may interact with a transcriptional coactivator.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,PTM:Acetylated.,similarity:Belongs to the SAP130 family.,subunit:Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2.,tissue specificity:Expressed in various cancer cell ines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
