产品名称
PLCB4 Rabbit Polyclonal Antibody
蛋白名称
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q15147
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15147/entry
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9QW07
免疫原
Synthesized peptide derived from part region of human protein
特异性
PLCB4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010],
组织表达
Preferentially expressed in the retina.
细胞定位
intracellular,nucleus,smooth endoplasmic reticulum,cytosol,postsynaptic density,dendrite,
信号通路
Inositol phosphate metabolism;Calcium;Chemokine;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;WNT;WNT-T CELLGap junction;Long-term potentiation;Long-term depression;GnRH;Melanogenesis;Alzheimer's disease;Huntington's disease;
功能
alternative products:Additional isoforms seem to exist,catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,tissue specificity:Preferentially expressed in the retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
