产品名称
PLCB1 Rabbit Polyclonal Antibody
蛋白名称
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NQ66
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NQ66/entry
Mouse Swissprot No.
Q9Z1B3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1B3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P10687
免疫原
Synthesized peptide derived from part region of human protein
特异性
PLCB1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Brain,Epithelium,Placenta,Testis,
细胞定位
Nucleus membrane . Cytoplasm . Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. .
信号通路
Inositol phosphate metabolism;Calcium;Chemokine;Phosphatidylinositol signaling system;Vascular smooth muscle contraction;WNT;WNT-T CELLGap junction;Long-term potentiation;Long-term depression;GnRH;Melanogenesis;Alzheimer's disease;Huntington's disease;
功能
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
