产品名称
SETB2 Rabbit Polyclonal Antibody
基因名称
SETDB2 C13orf4 CLLD8 KMT1F
蛋白名称
Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.43) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q96T68
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96T68/entry
Mouse Swissprot No.
Q8C267
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C267
免疫原
Synthesized peptide derived from part region of human protein
特异性
SETB2 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
SET domain bifurcated 2(SETDB2) Homo sapiens This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
组织表达
Ubiquitous. Highest expression in heart, testis and ovary.
细胞定位
Nucleus . Chromosome .
功能
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,function:Probable histone methyltransferase.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,similarity:Contains 1 pre-SET domain.,similarity:Contains 1 SET domain.,tissue specificity:Ubiquitous. Highest expression in heart, testis and ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
