RM3679

ZAP70 (12E7) Rabbit Monoclonal Antibody

SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70

常规抗体

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

A synthetic peptide of human ZAP70

WB: 1:2000-1:10000 IHC: 1:50-1:200 ICC/IF: 1:50-1:200 IP: 1:20-1:50

70kDa

70kDa

-20°C/1 year

Rabbit

IgG

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Affinity Purification