产品名称
KDM5D Rabbit Polyclonal Antibody
基因名称
KDM5D HY HYA JARID1D KIAA0234 SMCY
蛋白名称
Lysine-specific demethylase 5D (EC 1.14.11.-) (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BY66
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BY66/entry
Mouse Swissprot No.
Q62240
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62240
免疫原
Synthesized peptide derived from part region of human protein
特异性
KDM5D Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
组织表达
Expression is highly down-regulated in metastatic prostate tumors.
功能
alternative products:Additional isoforms seem to exist,cofactor:Ascorbate.,cofactor:Fe(2+).,domain:The JmjC domain is required for enzymatic activity.,function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Interacts with PCGF6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
