产品名称
ITA10 Rabbit Polyclonal Antibody
基因名称
ITGA10 UNQ468/PRO827
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75578
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75578/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
ITA10 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
组织表达
Widely expressed with highest expression in muscle and heart. Found in articular cartilage.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Focal adhesion;ECM-receptor interaction;Regulates Actin and Cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-10/beta-1 is a receptor for collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.,tissue specificity:Widely expressed with highest expression in muscle and heart. Found in articular cartilage.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
