产品名称
DHSO Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6652
Human Swissprot No.
Q00796
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q00796/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20322
Mouse Swissprot No.
Q64442
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64442
Rat Gene Link
https://www.uniprot.org/uniprot/24788
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P27867
免疫原
Synthesized peptide derived from human DHSO
特异性
This antibody detects endogenous levels of DHSO at Human/Mouse/Rat
稀释度
WB 1：500-2000 IP 1:200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010],
组织表达
Expressed in liver (PubMed:3365415). Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
细胞定位
Mitochondrion membrane ; Peripheral membrane protein . Cell projection, cilium, flagellum . Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. .
功能
catalytic activity:L-iditol + NAD(+) = L-sorbose + NADH.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
