产品名称
ITA10 Rabbit Polyclonal Antibody
基因名称
ITGA10 UNQ468/PRO827
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75578
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75578/entry
免疫原
Synthesized peptide derived from part region of human protein
特异性
ITA10 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
组织表达
Widely expressed with highest expression in muscle and heart. Found in articular cartilage.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Focal adhesion;ECM-receptor interaction;Regulates Actin and Cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-10/beta-1 is a receptor for collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.,tissue specificity:Widely expressed with highest expression in muscle and heart. Found in articular cartilage.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
