RM3468

53BP1 (13T9) Rabbit Monoclonal Antibody

TP53; p202; 53BP1; TDRD30; p53BP1

常规抗体

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

A synthetic peptide of human 53BP1

WB: 1:1000-1:2000 IHC: 1:20-1:50 ICC/IF: 1:20-1:50 FC: 1:20

450kDa

214kDa

-20°C/1 year

Rabbit

IgG

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Affinity Purification