产品名称
TRPM2 Rabbit Polyclonal Antibody
基因名称
TRPM2 EREG1 KNP3 LTRPC2 TRPC7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7226
Human Swissprot No.
O94759
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O94759/entry
Mouse Swissprot No.
Q91YD4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YD4
免疫原
Synthesized peptide derived from human TRPM2 AA range: 41-91
特异性
This antibody detects endogenous levels of TRPM2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016],
组织表达
Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.
细胞定位
Cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection . Cytoplasmic vesicle . Lysosome . Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). .; [Isoform 1]: Cell membrane ; Multi-pass membrane protein .; [Isoform 2]: Cell membrane ; Multi-pass membrane protein .; [Isoform 3]: Cell membrane ; Multi-pass membrane protein .
功能
catalytic activity:ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate.,function:Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.,induction:NAD(+).,similarity:Belongs to the transient receptor family. LTrpC subfamily.,similarity:Contains 1 nudix hydrolase domain.,subunit:Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.,tissue specificity:Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
