产品名称
HS74L Rabbit Polyclonal Antibody
蛋白名称
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O95757
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95757/entry
Mouse Swissprot No.
P48722
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P48722
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P83581
免疫原
Synthesized peptide derived from human protein . at AA range: 450-530
特异性
HS74L Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
细胞定位
Cytoplasm . Nucleus . May translocate to the nucleus after heat shock. .
功能
function:Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.,induction:By heat shock.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:May translocate to the nucleus after heat shock.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
