产品名称
GRIP1 Rabbit Polyclonal Antibody
蛋白名称
Glutamate receptor-interacting protein 1 (GRIP-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y3R0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y3R0/entry
Mouse Swissprot No.
Q925T6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q925T6
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97879
免疫原
Synthesized peptide derived from human protein . at AA range: 830-910
特异性
GRIP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
glutamate receptor interacting protein 1(GRIP1) Homo sapiens This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010],
组织表达
Fetal brain,PCR rescued clones,
细胞定位
Cytoplasmic vesicle . Perikaryon . Cell projection, dendrite . Cytoplasm . Endomembrane system ; Peripheral membrane protein . Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse, postsynaptic density . Endoplasmic reticulum membrane ; Peripheral membrane protein . Membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities. .
功能
domain:PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR.,function:May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.,similarity:Contains 7 PDZ (DHR) domains.,subcellular location:Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in post-synaptic plasma membrane and post-synaptic densities.,subunit:Interacts with EPHA7, EPHB2, KIF5A, KIF5B, KIF5C, GRIA2, GRIA3, GRIPAP1/GRASP1, PPFIA1, PPFIA4, FRAS1, PLCD4, PTPRF and liprins-alpha. Can form homomultimers or heteromultimers with GRIP2. Forms a ternary complex with GRIA2 and CSPG4 (By similarity). Interacts with EFNB1, EFNB3 and the C-terminal tail of PRLHR. Interacts with SLC30A9.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
