产品名称
DNJB2 Rabbit Polyclonal Antibody
蛋白名称
DnaJ homolog subfamily B member 2 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P25686
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P25686/entry
Mouse Swissprot No.
Q9QYI5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYI5
免疫原
Synthesized peptide derived from human protein . at AA range: 260-340
特异性
DNJB2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011],
组织表达
More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272).
细胞定位
[Isoform 2]: Cytoplasm . Nucleus .; [Isoform 1]: Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side .
功能
alternative products:Experimental confirmation may be lacking for some isoforms,similarity:Contains 1 J domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,tissue specificity:Brain (neuronal layers). Weakly, in skeletal muscle and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
