产品名称
DEDD Rabbit Polyclonal Antibody
基因名称
DEDD DEDPRO1 DEFT KE05
蛋白名称
Death effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75618
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75618/entry
Mouse Swissprot No.
Q9Z1L3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1L3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9Z2K0
免疫原
Synthesized peptide derived from human protein . at AA range: 90-170
特异性
DEDD Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed with highest levels in testis.
细胞定位
Cytoplasm. Nucleus, nucleolus . Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. .
功能
function:A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.,PTM:Exists predominantly in a mono- or diubiquitinated form.,similarity:Contains 1 DED (death effector) domain.,subcellular location:Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.,subunit:Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.,tissue specificity:Widely expressed with highest levels in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
