产品名称
HES2 Rabbit Polyclonal Antibody
蛋白名称
Transcription factor HES-2 (Class B basic helix-loop-helix protein 40) (bHLHb40) (Hairy and enhancer of split 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y543
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y543/entry
Mouse Swissprot No.
O54792
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54792
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P35429
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
HES2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
domain:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,domain:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,function:Transcriptional repressor of genes that require a bHLH protein for their transcription.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.,tissue specificity:Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.,
组织表达
Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
功能
domain:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,domain:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,function:Transcriptional repressor of genes that require a bHLH protein for their transcription.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.,tissue specificity:Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
