RM3146

RIP (19Z10) Rabbit Monoclonal Antibody

RIP; Rinp; Rip1; D330015H01Rik

常规抗体

WB

Mouse

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

Recombinant protein of mouse RIP

WB: 1:1000 ICC/IF: 1:200 FC: 1:200-1:500 IP: 1:20

75kDa

75kDa

-20°C/1 year

Rabbit

IgG

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.

Affinity Purification