RM3144

Phospho-p27 KIP 1 (Ser10) (11W17) Rabbit Monoclonal Antibody

KIP1; MEN4; CDKN4; MEN1B; P27KIP1

常规抗体

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

A synthetic phosphopeptide corresponding to residues surrounding Ser10 of human p27 KIP 1

WB: 1:1000 IHC: 1:50-1:200 IP: 1:20

27kDa

22kDa

-20°C/1 year

Rabbit

IgG

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

Affinity Purification